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Dysport versus Botox, the similarities and the differences.
Dysport was approved by the FDA in 2009 for wrinkles and muscle spasticity. It gives both physicians and patients a safe alternative in the neuromodulator market in the US and direct competition to Botox.
Dysport has been around for some time in Europe where it is known as Reloxin.
Dysport Facts compared to Botox
1.Both are derivatives of botulinum neurotoxin A and both last around 3-6 months post injection.
Both are effective for diminishing the dynamic lines between the brows (and other places as well). Typically the one offering the rebates to patients is usually the one that patients prefer. However, a small subset of patients have a direct preference for Botox and an equally small subset prefer Dysport. All other patients don't mind either one.
2.Dysport is less protein bound than Botox
This may theoretically convert to quicker onset of the neurotoxin. Where the effects of Botox may become clinically present in 4-5 days upt to 2 weeks, Dysport's effects may start to show at around 2 days unward.
The fact that it is less protein bound could also theoretically mean that less of an immune response could be present causing less breakdown of the molecule. This could lead to a longer presence of the neurotoxin which could mean a longer effect. 3. Packaged Differently
Botox is packaged at 100 units per vial whereas Dysport is 300 units per vial. Although both are equally safe and both are effective, there still remains controversy on the dosage ratio.
I currently use 2.5 units of Dysport to 1 unit of Botox. Other ratios that are used frequently are 3:1 ratios.
4. Slightly different cost
Dysport is slightly less expensive than Botox and currently there are rebates offered by Medicis which helps patients who are sitting on the fence.
All in all, it is nice to have some healthy, safe competition to Botox. There are several other neuromodulators in the pipeline so in the next 2-4 years, patients will hopefully see more competition in this arena which may convert to better pricing...
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